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Expression of smooth muscle MyHC B in blood vessels of hypertrophied heart in experimentally hypertensive rats

Item Type:Article
Title:Expression of smooth muscle MyHC B in blood vessels of hypertrophied heart in experimentally hypertensive rats
Creators Name:Wetzel, K. and Baltatu, O. and Nafz, B. and Persson, P.B. and Haase, H. and Morano, I.
Abstract:We demonstrated recently a significantly lower fraction of cardiac precapillary arterioles that expressed smooth muscle myosin heavy chain (MyHC) B (SMB) in spontaneously hypertensive rats. To clarify whether this reduction of SMB expression is of genetic origin, we investigated SMB expression in cardiac precapillary arterioles of normotensive and experimentally hypertensive rats (one clip, one kidney or ANG II minipump). We observed similar SMB expression patterns in precapillary arterioles of experimentally hypertensive rats compared with normotensive controls. These observations suggest that the downregulation of SMB in spontaneously hypertensive rats is of genetic origin rather than an adaptive response to chronically enhanced blood pressure and cardiac hypertrophy.
Keywords:Hypertension, Hypertrophy, Myosin Heavy Chain, Animals, Rats
Source:American Journal of Physiology Regulatory Integrative and Comparative Physiology
ISSN:0363-6119
Publisher:American Physiological Society (U.S.A.)
Volume:284
Number:2
Page Range:R607-R610
Date:1 February 2003
Official Publication:https://doi.org/10.1152/ajpregu.00578.2002
PubMed:View item in PubMed

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