Helmholtz Gemeinschaft

Search
Browse
Statistics
Feeds

Cardenamides from cardenolides: Cardiac and anticancer activities

Item Type:Article
Title:Cardenamides from cardenolides: Cardiac and anticancer activities
Creators Name:Megges, R., Weiland, J., Schoen, R., Repke, H. and Repke, K.R.H.
Abstract:Two ways are shown to transform cardioactive cardenolides into cardenamides [17{beta}-(5-oxo-2,5-dihydropyrrol-3-yl)-5{beta},14{beta}-androstane derivatives], and their derivatives by replacement of their ring oxygen by N-R. Cardioactivity is strongly decreased by this transformation. The comparatively easily accessible 21-oxocardenamides [17{beta}-(2-maleimidyl)steroids] are strongly thiol reactive and show remarkable anticancer activity.
Keywords:Na+/K+-ATPase Inhibition, Cardenolides, Cardenamides, Steroids, Lactams, 21-Oxocardenamides, Anticancer Activity
Source:Collection of Czechoslovak Chemical Communications
ISSN:0010-0765
Publisher:Institute of Organic Chemistry and Biochemistry
Volume:67
Number:3
Page Range:336-352
Date:2002
Official Publication:https://doi.org/10.1135/cccc20020336

Repository Staff Only: item control page

Open Access
MDC Library