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Genetic influence on neurogenesis in the dentate gyrus of adult mice

Item Type:Article
Title:Genetic influence on neurogenesis in the dentate gyrus of adult mice
Creators Name:Kempermann, G. and Kuhn, H.G. and Gage, F.H.
Abstract:To address genetic influences on hippocampal neurogenesis in adult mice, we compared C57BL/6, BALB/c, CD1(ICR), and 129Sv/J mice to examine proliferation, survival, and differentiation of newborn cells in the dentate gyrus. Proliferation was highest in C57BL/6; the survival rate of newborn cells was highest in CD1. In all strains approximately 60% of surviving newborn cells had a neuronal phenotype, but 129/SvJ produced more astrocytes. Over 6 days C57BL/6 produced 0.36% of their total granule cell number of 239,000 as new neurons, BALB/c 0.30% of 242,000, CD1 (ICR) 0.32% of 351,000, and 129/SvJ 0.16% of 280,000. These results show that different aspects of adult hippocampal neurogenesis are differentially influenced by the genetic background.
Keywords:Cell Differentiation, Cell Division, Cell Survival, Dentate Gyrus, Immunohistochemistry, Confocal Microscopy, Neurons, Species Specificity, Animals, Mice
Source:Proceedings of the National Academy of Sciences of the United States of America
ISSN:0027-8424
Publisher:National Academy of Sciences (U.S.A.)
Volume:94
Number:19
Page Range:10409-10414
Date:16 September 1997
Official Publication:http://www.pnas.org/content/94/19/10409.abstract
PubMed:View item in PubMed

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