Tumor rejection by disturbing tumor stroma cell interactions

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Item Type:	Article
Title:	Tumor rejection by disturbing tumor stroma cell interactions
Creators Name:	Ibe, S., Qin, Z.H., Schueler, T., Preiss, S. and Blankenstein, T.
Abstract:	The stroma of solid tumors is a complex network of different cell types. We analyzed stroma cell interactions in two tumor models during cyclophosphamide (Cy)-induced tumor rejection. In growing tumors, tumor infiltrating macrophages (TIMs) produced interleukin (IL)-10. Beginning 6 h after Cy-treatment T cells in the tumor were inactivated and TIMs switched to interferon (IFN)-gamma production. Both, IL-10 production before and IFN-gamma production after Cy-treatment by TIMs required T cells. With the same kinetics as TIMs started to produce IFN-gamma the tumor vasculature was destroyed which required IFN-gamma receptor expression on host but not tumor cells. These events preceded hemorrhagic necrosis and residual tumor cell elimination by T cells. Together, T cells regulate the function of TIMs and tumor rejection can be induced by disturbing the stroma network.
Keywords:	Tumor Stroma, Tumor Infiltrating Macrophages, IFN-gamma, Antiangiogenesis, Cyclophosphamid, Animals, Mice
Source:	Journal of Experimental Medicine
ISSN:	0022-1007
Publisher:	Rockefeller University Press
Volume:	194
Number:	11
Page Range:	1549-1559
Date:	3 December 2001
Official Publication:	https://doi.org/10.1084/jem.194.11.1549
PubMed:	View item in PubMed

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