Augmentation of BNP gene expression in atria by pressure overload in transgenic rats harbouring human renin and angiotensinogen genes

Item Type:	Article
Title:	Augmentation of BNP gene expression in atria by pressure overload in transgenic rats harbouring human renin and angiotensinogen genes
Creators Name:	Marttila, M. and Puhakka, J. and Luodonpaeae, M. and Vuolteenaho, O. and Ganten, U. and Ruskoaho, H.
Abstract:	We studied the role of angiotensin II in pressure overload-induced B-type natriuretic peptide (BNP) gene expression by using a double transgenic rat (dTGR) model, in which transgenic rats for the human angiotensinogen and renin genes are crossed. Pressure overload produced by [Arg8]-vasopressin (AVP) infusion (i.v., 0.05 microg/kg/min for 2 h) in conscious, chronically instrumented rats, resulted in a significantly greater increase in BNP mRNA levels in the left atrium of the dTGR rats than in Sprague-Dawley (SD) control rats (3.6- vs 1.6-fold, p < 0.05), while in the left ventricle there was no significant difference between the strains. In dTGR rats, the early activation of the BNP gene expression was associated with a decrease in immunoreactive BNP levels in the atrium (27.5%, p < 0.05), but not in the ventricle. In SD rats, ir-BNP levels did not change significantly in either atria or ventricles in response to AVP infusion. These results show that the pressure overload-induced activation of BNP gene expression differs between atrial and ventricular myocytes in the dTGR model of experimental hypertension.
Keywords:	Angiotensinogen, Animal Disease Models, Atrial Natriuretic Factor, Blood Pressure, Brain Natriuretic Peptide, Gene Expression, Genetically Modified Animals, Heart Atria, Hypertension, Messenger RNA, Renin, Animals, Rats
Source:	Blood Pressure
ISSN:	0803-7051
Volume:	8
Number:	5-6
Page Range:	308-316
Date:	1999
Official Publication:	https://doi.org/10.1080/080370599439535
PubMed:	View item in PubMed

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