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| Item Type: | Article |
|---|---|
| Title: | Growth hormone therapy in heart failure |
| Creators Name: | Strohm, O., Friedrich, M.G., von Harsdorf, R., Osterziel, K.J. and Dietz, R. |
| Abstract: | Clinical and experimental data in animals and patients with endstage heart failure due to dilated cardiomyopathy or ischemic heart disease suggest a beneficial role of growth factors like human recombinant growth hormone or insulin-like growth factor I. Their cardiac effects are an increase in myocardial mass and a decrease in systolic wall stress. Based on the results of animal studies and of preliminary studies in patients with dilated cardiomyopathy, double-blind and placebo-controlled studies have proven the increase in myocardial mass and a significant reduction of left ventricular wall stress, as demonstrated by magnetic resonance imaging.The risk of the additional therapy with human growth factors in this high-risk group of patients with a high mortality is justified, if this new approach becomes a possible alternative to cardiac transplantation or a bridge toward transplantation.If future randomized studies in larger patient groups with an individualized substitution therapy with growth hormone and/or IGF-I can demonstrate a beneficial effect on mortality and morbidity, this new therapeutic approach could become an attractive alternative in these high-risk patients. |
| Keywords: | Heart Failure, IGF-I, Growth Hormone, Dilated Cardiomyopathy, Review |
| Source: | Zeitschrift fuer Kardiologie |
| ISSN: | 0300-5860 |
| Publisher: | Steinkopff |
| Volume: | 88 |
| Number: | Suppl 3 |
| Page Range: | S40-S46 |
| Date: | October 1999 |
| Official Publication: | https://doi.org/10.1007/s003920050587 |
| PubMed: | View item in PubMed |
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