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The fibroblast growth factor receptor FGFR-4 acts as a ligand dependent modulator of erythroid cell proliferation

Item Type:Article
Title:The fibroblast growth factor receptor FGFR-4 acts as a ligand dependent modulator of erythroid cell proliferation
Creators Name:Koritschoner, N.P. and Bartunek, P. and Knespel, S. and Blendinger, G. and Zenke, M.
Abstract:Receptor and non-receptor tyrosine kinases constitute a large family of proteins that play a pivotal role in hematopoiesis. Here we conducted a comprehensive survey of tyrosine kinase gene expression in primary erythroid progenitor cells from bone marrow by employing a PCR-based strategy that targets the conserved kinase encoding region. We demonstrate that erythroid progenitor cells express several receptor and non-receptor tyrosine kinases, like c-kit, Jak1, Ryk, FAK, Syk, Arg, Csk and members of the insulin receptor family. Specific changes in the expression profile of tyrosine kinases were observed following differentiation induction. We also report on the identification of a new ligand dependent modulator of erythropoiesis, fibroblast growth factor receptor-4 (FGFR-4). FGFR-4 is effectively expressed in erythroid progenitors and downregulated when cells differentiate. Furthermore, the FGFR-4 ligand, basic fibroblast growth factor (bFGF), enhanced erythroid cell proliferation induced by SCF or insulin, and thus modulated both erythroid proliferation and differentiation in vitro.
Keywords:Fibroblast Growth Factor, FGFR-4, bFGF, Tyrosine Kinase, Erythroid Cells, Hematopoiesis, Animals, Chickens
Source:Oncogene
ISSN:0950-9232
Publisher:Nature Publishing Group (U.K.)
Volume:18
Number:43
Page Range:5904-5914
Date:21 October 1999
Official Publication:http://www.nature.com/onc/journal/v18/n43/full/1202979a.html
PubMed:View item in PubMed

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