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ICOS is an inducible T-cell co-stimulator structurally and functionally related to CD28

Official URL:https://doi.org/10.1038/16717
PubMed:View item in PubMed
Creators Name:Hutloff, A. and Dittrich, A.M. and Beier, K.C. and Eljaschewitsch, B. and Kraft, R. and Anagnostopoulos, I. and Kroczek, R.A.
Journal Title:Nature
Journal Abbreviation:Nature
Volume:397
Number:6716
Page Range:263-266
Date:21 January 1999
Keywords:Amino Acid Sequence, CD28 Antigens, Cell Communication, Cell Line, Germinal Center, Inducible T-Cell Co-Stimulator Protein, Lymphocyte Activation, Molecular Cloning, Molecular Sequence Data, Monoclonal Antibodies, T-Lymphocyte Differentiation Antigens, T-Lymphocytes, Animals, Mice
Abstract:The T-cell-specific cell-surface receptors CD28 and CTLA-4 are important regulators of the immune system. CD28 potently enhances those T-cell functions that are essential for an effective antigen-specific immune response, and the homologous CTLA-4 counterbalances the CD28-mediated signals and thus prevents an otherwise fatal overstimulation of the lymphoid system. Here we report the identification of a third member of this family of molecules, inducible co-stimulator (ICOS), which is a homodimeric protein of relative molecular mass 55,000-60,000 (M(r) 55K-60K). Matching CD28 in potency, ICOS enhances all basic T-cell responses to a foreign antigen, namely proliferation, secretion of lymphokines, upregulation of molecules that mediate cell-cell interaction, and effective help for antibody secretion by B cells. Unlike the constitutively expressed CD28, ICOS has to be de novo induced on the T-cell surface, does not upregulate the production of interleukin-2, but superinduces the synthesis of interleukin-10, a B-cell-differentiation factor. In vivo, ICOS is highly expressed on tonsillar T cells, which are closely associated with B cells in the apical light zone of germinal centres, the site of terminal B-cell maturation. Our results indicate that ICOS is another major regulator of the adaptive immune system.
ISSN:0028-0836
Publisher:Nature Publishing Group (U.K.)
Item Type:Article

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