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Newly synthesized L-enantiomers of 3'-fluoro-modified beta-2'- deoxyribonucleoside 5'-triphosphates inhibit hepatitis B DNA polymerases but not the five cellular DNA polymerases alpha, beta, gamma, delta and epsilon nor HIV-1 reverse transcriptase

Item Type:Article
Title:Newly synthesized L-enantiomers of 3'-fluoro-modified beta-2'- deoxyribonucleoside 5'-triphosphates inhibit hepatitis B DNA polymerases but not the five cellular DNA polymerases alpha, beta, gamma, delta and epsilon nor HIV-1 reverse transcriptase
Creators Name:von Janta-Lipinski, M., Costisella, B., Ochs, H., Huebscher, U., Hafkemeyer, P. and Matthes, E.
Keywords:DNA Polymerase I, DNA Polymerase II, DNA Polymerase III, DNA Polymerase beta, DNA-Directed DNA Polymerase, Duck Hepatitis B Virus, Enzyme Inhibitors, HeLa Cells, Hepatitis B, HIV Reverse Transcriptase, Kinetics, Organophosphates, Placenta, Pyrimidine Nucleosides, Reverse Transcriptase Inhibitors, Stereoisomerism, Structure-Activity Relationship, Animals, Cattle
Source:Journal of Medicinal Chemistry
ISSN:0022-2623
Volume:41
Page Range:2040-2046
Date:1 January 1998
PubMed:View item in PubMed

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