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| Item Type: | Article |
|---|---|
| Title: | Human mu-opioid receptor variation and alcohol dependence |
| Creators Name: | Sander, T., Gscheidel, N., Wendel, B., Samochowiec, J., Smolka, M., Rommelspacher, H., Schmidt, L.G. and Hoehe, M.R. |
| Abstract: | Mu-Opioid receptor-mediated neurotransmission is involved in the reward, tolerance, and withdrawal effects of alcohol. The present association study tested the hypothesis that the common Asn40Asp substitution polymorphism in the N-terminal domain of the human mu-opioid receptor (OPRM) confers vulnerability to subtypes of alcohol dependence. The genotypes of the Asn40Asp substitution polymorphism were assessed in 327 German alcohol-dependent subjects (according to ICD-10) and in 340 control subjects of German descent, using an assay based on allele-specific polymerase chain reaction. To select alcoholics with a presumed high genetic load, three subgroups were delineated, marked by (1) a family history of parental alcoholism (n = 114); (2) the inability to abstain from alcohol before the age of 26 years (n = 73); and (3) a history of alcohol withdrawal seizure or delirium (n = 107). The frequency of the Asp40 allele did not differ significantly between the controls [f(Asp40) = 0.078] and either the entire group of alcoholics [f(Asp40) = 0.107; p = 0.066], or the alcoholics with parental alcoholism [f(Asp40) = 0.114; p = 0.094], or the early-onset alcoholics [f(Asp40) = 0.096; p = 0.471,[ or the alcoholics with severe withdrawal symptoms [f(Asp40) = 0.098; p = 0.350]. Our results do not provide evidence that the common Asn40Asp substitution polymorphism of the OPRM gene contributes a major effect to the pathogenesis of alcohol dependence. |
| Keywords: | Alcohol Withdrawal Delirium, Alcoholism, Alleles, Gene Frequency, Population Genetics, Genotype, Germany, Genetic Polymorphism, mu Opioid Receptors, Risk Factors |
| Source: | Alcoholism, Clinical and Experimental Research |
| ISSN: | 0145-6008 |
| Publisher: | Blackwell Publishing |
| Volume: | 22 |
| Number: | 9 |
| Page Range: | 2108-2110 |
| Date: | December 1998 |
| Official Publication: | https://doi.org/10.1111/j.1530-0277.1998.tb05923.x |
| PubMed: | View item in PubMed |
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