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Serotonin transporter-dependent histone serotonylation in placenta contributes to the neurodevelopmental transcriptome

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Item Type:Article
Title:Serotonin transporter-dependent histone serotonylation in placenta contributes to the neurodevelopmental transcriptome
Creators Name:Chan, J.C., Alenina, N., Cunningham, A.M., Ramakrishnan, A., Shen, Li, Bader, M. and Maze, I.
Abstract:Brain development requires appropriate regulation of serotonin (5-HT) signaling from distinct tissue sources across embryogenesis. At the maternal-fetal interface, the placenta is thought to be an important contributor of offspring brain 5-HT and is critical to overall fetal health. Yet, how placental 5-HT is acquired, and the mechanisms through which 5-HT influences placental functions, are not well understood. Recently, our group identified a novel epigenetic role for 5-HT, in which 5-HT can be added to histone proteins to regulate transcription, a process called H3 serotonylation. Here, we show that H3 serotonylation undergoes dynamic regulation during placental development, corresponding to gene expression changes that are known to influence key metabolic processes. Using transgenic mice, we demonstrate that placental H3 serotonylation is dependent on 5-HT uptake by the serotonin transporter (SERT/SLC6A4). SERT deletion robustly reduces enrichment of H3 serotonylation across the placental genome, and disrupts neurodevelopmental gene networks in early embryonic brain tissues. Thus, these findings suggest a novel role for H3 serotonylation in coordinating placental transcription at the intersection of maternal physiology and offspring brain development.
Keywords:Epigenetics, Development, Serotonin Transporter, H3 Serotonylation, Placenta, Animals, Mice
Source:Journal of Molecular Biology
ISSN:0022-2836
Publisher:Elsevier
Volume:436
Number:7
Page Range:168454
Date:1 April 2024
Official Publication:https://doi.org/10.1016/j.jmb.2024.168454
PubMed:View item in PubMed

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