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| Item Type: | Article |
|---|---|
| Title: | Matters arising: Insufficient evidence that pancreatic β cells are derived from adult ductal Neurog3-expressing progenitors |
| Creators Name: | Magenheim, J., Maestro, M.A., Sharon, N., Herrera, P.L., Murtaugh, L.C., Kopp, J., Sander, M., Gu, G., Melton, D.A., Ferrer, J. and Dor, Y. |
| Abstract: | Understanding the origin of pancreatic β cells has profound implications for regenerative therapies in diabetes. For over a century, it was widely held that adult pancreatic duct cells act as endocrine progenitors, but lineage-tracing experiments challenged this dogma. Gribben et al. recently used two existing lineage-tracing models and single-cell RNA sequencing to conclude that adult pancreatic ducts contain endocrine progenitors that differentiate to insulin-expressing β cells at a physiologically important rate. We now offer an alternative interpretation of these experiments. Our data indicate that the two Cre lines that were used directly label adult islet somatostatin-producing ∂ cells, which precludes their use to assess whether β cells originate from duct cells. Furthermore, many labeled ∂ cells, which have an elongated neuron-like shape, were likely misclassified as β cells because insulin-somatostatin coimmunolocalizations were not used. We conclude that most evidence so far indicates that endocrine and exocrine lineage borders are rarely crossed in the adult pancreas. |
| Keywords: | Pancreas, Beta Cells, Delta Cells, Stem Cells, Progenitor Cells, Ducts, Neogenesis, NEUROG3, Lineage Tracing, Beta Cell Regeneration |
| Source: | Cell Stem Cell |
| ISSN: | 1934-5909 |
| Publisher: | Cell Press |
| Volume: | 30 |
| Number: | 4 |
| Page Range: | 488-497 |
| Date: | 6 April 2023 |
| Official Publication: | https://doi.org/10.1016/j.stem.2023.03.003 |
| PubMed: | View item in PubMed |
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