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Autoimmunenzephalitis - ein Update [Autoimmune encephalitis - an update]

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Item Type:Article
Title:Autoimmunenzephalitis - ein Update [Autoimmune encephalitis - an update]
Creators Name:Heine, J. and Duchow, A. and Rust, R. and Paul, F. and Prüß, H. and Finke, C.
Abstract:Detection of autoantibodies against neurons and glia cells has brought about the early and specific diagnosis of autoimmune encephalitis in patients with variable neurological and psychiatric symptoms. Growing knowledge not only resulted in profound changes in treatment algorithms including immunotherapy but also in the understanding of disease mechanisms and etiological factors. The still increasing numbers of new autoantibodies calls for continuous updates on the state of the art in antibody diagnostics, frequencies of associated tumors and the clinical spectrum linked to each antibody, which can range from mood changes, cognitive impairment and epileptic seizures to abnormal movements, autonomic dysfunction and impaired levels of consciousness. This article summarizes the recent developments in the predominant clinical presentations of autoimmune encephalitis patients in imaging and cerebrospinal fluid diagnostics and also in prognostic markers, in the establishment of innovative immunotherapies, in the use of diagnostic pathways even before the results of the antibody tests are available and the understanding of the autoimmune etiology.
Keywords:Autoimmune Encephalitis, NMDA, NMDA Receptor, Encephalitis, Antibodies, Diagnostic Criteria, MRI, Cerebrospinal Fluid, Therapy, Outcomes
Source:Nervenarzt
ISSN:0028-2804
Publisher:Springer
Volume:94
Number:6
Page Range:525-537
Date:June 2023
Official Publication:https://doi.org/10.1007/s00115-022-01411-1
PubMed:View item in PubMed

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