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| Item Type: | Article |
|---|---|
| Title: | Pre-diagnostic circulating resistin concentrations are not associated with colorectal cancer risk in the European Prospective Investigation into Cancer and Nutrition study |
| Creators Name: | Pham, T.T. and Nimptsch, K. and Aleksandrova, K. and Jenab, M. and Reichmann, R. and Wu, K. and Tjønneland, A. and Kyrø, C. and Schulze, M.B. and Kaaks, R. and Katzke, V. and Palli, D. and Pasanisi, F. and Ricceri, F. and Tumino, R. and Krogh, V. and Roodhart, J. and Castilla, J. and Sánchez, M.J. and Colorado-Yohar, S.M. and Harbs, J. and Rutegård, M. and Papier, K. and Aglago, E.K. and Dimou, N. and Mayen-Chacon, A.L. and Weiderpass, E. and Pischon, T. |
| Abstract: | Resistin is a polypeptide implicated in inflammatory processes, and as such could be linked to colorectal carcinogenesis. In case-control studies, higher resistin levels have been found in colorectal cancer (CRC) patients compared to healthy individuals. However, evidence for the association between pre-diagnostic resistin and CRC risk is scarce. We investigated pre-diagnostic resistin concentrations and CRC risk within the European Prospective Investigation into Cancer and Nutrition using a nested case-control study among 1293 incident CRC-diagnosed cases and 1293 incidence density-matched controls. Conditional logistic regression models controlled for matching factors (age, sex, study center, fasting status, and women-related factors in women) and potential confounders (education, dietary and lifestyle factors, body mass index (BMI), BMI-adjusted waist circumference residuals) were used to estimate relative risks (RRs) and 95% confidence intervals (CIs) for CRC. Higher circulating resistin concentrations were not associated with CRC (RR per doubling resistin, 1.11; 95% CI 0.94-1.30; p= 0.22). There were also no associations with CRC subgroups defined by tumor subsite or sex. However, resistin was marginally associated with a higher CRC risk among participants followed-up maximally two years, but not among those followed-up after more than two years. We observed no substantial correlation between baseline circulating resistin concentrations and adiposity measures (BMI, waist circumference), adipokines (adiponectin, leptin), or metabolic and inflammatory biomarkers (C-reactive protein, C-peptide, high-density lipoprotein cholesterol, reactive oxygen metabolites) among controls. In this large-scale prospective cohort, there was little evidence of an association between baseline circulating resistin concentrations and CRC risk in European men and women. |
| Keywords: | Pre-Diagnostic Resistin, Colorectal Cancer, Risk, Prospective, Inflammation |
| Source: | Cancers |
| ISSN: | 2072-6694 |
| Publisher: | MDPI |
| Volume: | 14 |
| Number: | 22 |
| Page Range: | 5499 |
| Date: | 9 November 2022 |
| Official Publication: | https://doi.org/10.3390/cancers14225499 |
| PubMed: | View item in PubMed |
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