Helmholtz Gemeinschaft

Search
Browse
Statistics
Feeds

MicroRNAs are deeply linked to the emergence of the complex octopus brain

[thumbnail of Original Article]
Preview
PDF (Original Article) - Requires a PDF viewer such as GSview, Xpdf or Adobe Acrobat Reader
1MB
[thumbnail of Supplementary Materials] Other (Supplementary Materials)
24MB

Item Type:Article
Title:MicroRNAs are deeply linked to the emergence of the complex octopus brain
Creators Name:Zolotarov, G., Fromm, B., Legnini, I., Ayoub, S., Polese, G., Maselli, V., Chabot, P.J., Vinther, J., Styfhals, R., Seuntjens, E., Di Cosmo, A., Peterson, K.J. and Rajewsky, N.
Abstract:Soft-bodied cephalopods such as octopuses are exceptionally intelligent invertebrates with a highly complex nervous system that evolved independently from vertebrates. Because of elevated RNA editing in their nervous tissues, we hypothesized that RNA regulation may play a major role in the cognitive success of this group. We thus profiled messenger RNAs and small RNAs in three cephalopod species including 18 tissues of the (Octopus vulgaris). We show that the major RNA innovation of soft-bodied cephalopods is an expansion of the microRNA (miRNA) gene repertoire. These evolutionarily novel miRNAs were primarily expressed in adult neuronal tissues and during the development and had conserved and thus likely functional target sites. The only comparable miRNA expansions happened, notably, in vertebrates. Thus, we propose that miRNAs are intimately linked to the evolution of complex animal brains.
Keywords:Brain, Messenger RNA, MicroRNAs, Seafood, Animals, Octopodiformes
Source:Science Advances
ISSN:2375-2548
Publisher:American Association for the Advancement of Science
Volume:8
Number:47
Page Range:eadd9938
Date:25 November 2022
Official Publication:https://doi.org/10.1126/sciadv.add9938
PubMed:View item in PubMed

Repository Staff Only: item control page

Downloads

Downloads per month over past year

Open Access
MDC Library