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| Item Type: | Article |
|---|---|
| Title: | Satellite glia of the adult dorsal root ganglia harbor stem cells that yield glia under physiological conditions and neurons in response to injury |
| Creators Name: | Maniglier, M. and Vidal, M. and Bachelin, Corinne and Deboux, C. and Chazot, J. and Garcia-Diaz, B. and Baron-Van Evercooren, A. |
| Abstract: | The presence of putative stem/progenitor cells has been suggested in adult peripheral nervous system (PNS) tissue, including the dorsal root ganglion (DRG). To date, their identification and fate in pathophysiological conditions have not been addressed. Combining multiple in vitro and in vivo approaches, we identified the presence of stem cells in the adult DRG satellite glial population, and progenitors were present in the DRGs and sciatic nerve. Cell-specific transgenic mouse lines highlighted the proliferative potential of DRG stem cells and progenitors in vitro. DRG stem cells had gliogenic and neurogenic potentials, whereas progenitors were essentially gliogenic. Lineage tracing showed that, under physiological conditions, adult DRG stem cells maintained DRG homeostasis by supplying satellite glia. Under pathological conditions, adult DRG stem cells replaced DRG neurons lost to injury in addition of renewing the satellite glial pool. These novel findings open new avenues for development of therapeutic strategies targeting DRG stem cells for PNS disorders. |
| Keywords: | Stem Cells, DRG, Satellite Glial Cells, Peripheral Nerve, Injury, CNS, Spinal Cord, Animals, Mice |
| Source: | Stem Cell Reports |
| ISSN: | 2213-6711 |
| Publisher: | Cell Press / Elsevier |
| Volume: | 17 |
| Number: | 11 |
| Page Range: | 2467-2483 |
| Date: | 8 November 2022 |
| Official Publication: | https://doi.org/10.1016/j.stemcr.2022.10.002 |
| PubMed: | View item in PubMed |
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