Stem cells versus plasticity in liver and pancreas regeneration

Item Type:	Review
Title:	Stem cells versus plasticity in liver and pancreas regeneration
Creators Name:	Kopp, J.L. and Grompe, M. and Sander, M.
Abstract:	Cell replacement in adult organs can be achieved through stem cell differentiation or the replication or transdifferentiation of existing cells. In the adult liver and pancreas, stem cells have been proposed to replace tissue cells, particularly following injury. Here we review how specialized cell types are produced in the adult liver and pancreas. Based on current evidence, we propose that the plasticity of differentiated cells, rather than stem cells, accounts for tissue repair in both organs.
Keywords:	Cell Differentiation, Cell Transdifferentiation, Liver, Pancreas, Regeneration, Stem Cells / Cytology, Animals
Source:	Nature Cell Biology
ISSN:	1465-7392
Publisher:	Nature Publishing Group
Volume:	18
Number:	3
Page Range:	238-45
Date:	March 2016
Official Publication:	https://doi.org/10.1038/ncb3309
PubMed:	View item in PubMed

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