NETs and cell cycle regulation

Item Type:	Article
Title:	NETs and cell cycle regulation
Creators Name:	Robson, M.I. and Le Thanh, P. and Schirmer, E.C.
Abstract:	There are many ways that the nuclear envelope can influence the cell cycle. In addition to roles of lamins in regulating the master cell cycle regulator pRb and nuclear envelope breakdown in mitosis, many other nuclear envelope proteins influence the cell cycle through regulatory or structural functions. Of particular note among these are the nuclear envelope transmembrane proteins (NETs) that appear to influence cell cycle regulation through multiple separate mechanisms. Some NETs and other nuclear envelope proteins accumulate on the mitotic spindle, suggesting functional or structural roles in the cell cycle. In interphase exogenous overexpression of some NETs promotes an increase in G1 populations, while others promote an increase in G2/M populations, sometimes associated with the induction of senescence. Intriguingly, most of the NETs linked to the cell cycle are highly restricted in their tissue expression; thus, their misregulation in cancer could contribute to the many tissue-specific types of cancer.
Keywords:	Cell Cycle, Membrane Proteins, Neoplasms, Nuclear Envelope
Source:	Advances in experimental medicine and biology
Series Name:	Advances in Experimental Medicine and Biology
Title of Book:	Cancer Biology and the Nuclear Envelope
ISSN:	0065-2598
ISBN:	978-148998031-1
Publisher:	Springer
Volume:	773
Number:	773
Page Range:	165-85
Number of Pages:	611
Date:	1 January 2014
Official Publication:	https://doi.org/10.1007/978-1-4899-8032-8_8
PubMed:	View item in PubMed

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