Shared sugars - parasite glycan homology in HIV-1 vaccine design

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Item Type:	Editorial
Title:	Shared sugars - parasite glycan homology in HIV-1 vaccine design
Creators Name:	Deimel, L.P. and Sattentau, Q.J.
Abstract:	Immune tolerance to self-glycans is a host mechanism to avoid autoimmunity, which is exploited by HIV-1 coating its envelope glycoproteins with glycans to evade neutralising antibodies (nAbs). Huettner et al. describe cross-reactivity between Schistosoma mansoni glycans and HIV-1 envelope glycoprotein glycans, suggesting a strategy for induction of HIV-1 nAbs by vaccination.
Keywords:	HIV-1, Antibody, Glycan, Parasite, Helminth, Animals
Source:	Trends in Parasitology
ISSN:	1471-4922
Publisher:	Elsevier
Volume:	38
Number:	7
Page Range:	498-500
Date:	July 2022
Official Publication:	https://doi.org/10.1016/j.pt.2022.04.001
PubMed:	View item in PubMed

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