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| Item Type: | Article |
|---|---|
| Title: | A high-resolution map of small-scale inversions in the gibbon genome |
| Creators Name: | Mercuri, L. and Palmisano, D. and L'Abbate, A. and D'Addabbo, P. and Montinaro, F. and Catacchio, C.R. and Hasenfeld, P. and Ventura, M. and Korbel, J.O. and Sanders, A.D. and Maggiolini, F.A.M. and Antonacci, F. |
| Abstract: | Gibbons are the most speciose family of living apes, characterized by a strikingly diverse chromosome number and rapid rate of large-scale rearrangements. Here we performed single-cell template strand sequencing (Strand-seq), molecular cytogenetics and deep in silico analysis of a southern white-cheeked gibbon genome providing the first comprehensive map of 238 previously hidden small-scale inversions. We determined that more than half are gibbon-specific, at least 5-fold higher than shown for other primate lineage specific inversions, with a significant high number of small heterozygous inversions, suggesting that accelerated evolution of inversions may have played a role in the high sympatric diversity of gibbons. Although the precise mechanisms underlying these inversions are not yet understood, it is clear that segmental duplication-mediated NAHR only accounts for a small fraction of events. Several genomic features including gene density and repeat (e.g. LINE1) content might render these regions more break-prone and susceptible to inversion formation. In the attempt to characterize interspecific variation between southern and northern white-cheeked gibbons, we identify several large assembly errors in the current GGSC Nleu3.0/nomLeu3 reference genome comprising over 49 megabases of DNA. Finally, we provide a list of 182 candidate genes potentially involved in gibbons diversification and speciation. |
| Keywords: | Chromosome Inversion, Chromosomes, Genome, Hominidae, Hylobates, Animals, Primates |
| Source: | Genome Research |
| ISSN: | 1088-9051 |
| Publisher: | Cold Spring Harbor Laboratory Press |
| Volume: | 32 |
| Number: | 10 |
| Page Range: | 1941-1951 |
| Date: | October 2022 |
| Additional Information: | This article is distributed exclusively by Cold Spring Harbor Laboratory Press for the first six months after the full-issue publication date (see https://genome.cshlp.org/site/misc/terms.xhtml). After six months, it is available under a Creative Commons License (Attribution-NonCommercial 4.0 International), as described at http://creativecommons.org/licenses/by-nc/4.0/. |
| Official Publication: | https://doi.org/10.1101/gr.276960.122 |
| PubMed: | View item in PubMed |
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