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| Item Type: | Article |
|---|---|
| Title: | Prognostic impact of activin subunit inhibin beta A in gastric and esophageal adenocarcinomas |
| Creators Name: | Staudacher, J.J. and Arnold, A. and Kühl, A.A. and Pötzsch, M. and Daum, S. and Winterfeld, M. and Berg, E. and Hummel, M. and Rau, B. and Stein, U. and Treese, C. |
| Abstract: | PURPOSE: Adenocarcinomas of the esophagus (AEG) and stomach (AS) are among the most common cancers worldwide. Novel markers for risk stratification and guiding treatment are strongly needed. Activin is a multi-functional cytokine with context specific pro- and anti-tumorigenic effects. We aimed to investigate the prognostic role of activin tumor protein expression in AEG/ASs. METHODS: Tissue from a retrospective cohort of 277 patients with AEG/AS treated primarily by surgery at the Charité - Universitätsmedizin Berlin was collected and analyzed by immunohistochemistry using a specific antibody to the activin homodimer inhibin beta A. Additionally, we evaluated T-cell infiltration and PD1 expression as well as expression of PD-L1 by immunohistochemistry as possible confounding factors. Clinico-pathologic data were collected and correlated with activin protein expression. RESULTS: Out of 277 tumor samples, 72 (26.0%) exhibited high activin subunit inhibin beta A protein expression. Higher expression was correlated with lower Union for International Cancer Control (UICC) stage and longer overall survival. Interestingly, activin subunit expression correlated with CD4(+) T-cell infiltration, and the correlation with higher overall survival was exclusively seen in tumors with high CD4(+) T-cell infiltration, pointing towards a role of activin in the tumor immune response in AEG/ASs. CONCLUSION: In our cohort of AEG/AS, higher activin subunit levels were correlated with longer overall survival, an effect exclusively seen in tumors with high CD4(+) cell infiltration. Further mechanistic research is warranted discerning the exact effect of this context specific cytokine. |
| Keywords: | Gastric Adenocarcinoma, Esophageal Adenocarcinoma, Activin, INHBA, TGF-ß Superfamily, Animals |
| Source: | BMC Cancer |
| ISSN: | 1471-2407 |
| Publisher: | BioMed Central |
| Volume: | 22 |
| Number: | 1 |
| Page Range: | 953 |
| Date: | 5 September 2022 |
| Official Publication: | https://doi.org/10.1186/s12885-022-10016-5 |
| PubMed: | View item in PubMed |
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