Helmholtz Gemeinschaft

Search
Browse
Statistics
Feeds

Autophagy dictates metabolism and differentiation of inflammatory immune cells

[thumbnail of Publisher's version]
Preview
PDF (Publisher's version) - Requires a PDF viewer such as GSview, Xpdf or Adobe Acrobat Reader
629kB

Item Type:Review
Title:Autophagy dictates metabolism and differentiation of inflammatory immune cells
Creators Name:Riffelmacher, T., Richter, F.C. and Simon, A.K.
Abstract:The role of macroautophagy/autophagy, a conserved lysosomal degradation pathway, during cellular differentiation has been well studied over the last decade. In particular, evidence for its role during immune cell differentiation is growing. Despite the description of a variety of dramatic immune phenotypes in tissue-specific autophagy knockout models, the underlying mechanisms are still under debate. One of the proposed mechanisms is the impact of autophagy on the altered metabolic states during immune cell differentiation. This concept is strengthened through novel molecular insights into how AMPK and MTOR signaling cascades affect both autophagy and metabolism. In this review, we discuss direct and indirect evidence linking autophagy, metabolic pathways and immune cell differentiation including T, B, and innate lymphocytes as well as in myeloid cells that are direct mediators of inflammation. Herein, we propose a model for autophagy-driven immunometabolism controlling immune cell differentiation.
Keywords:Autophagy, Differentiation, Hematopoiesis, Immune Cells, Inflammation, Metabolism, Animals
Source:Autophagy
ISSN:1554-8627
Publisher:Taylor & Francis
Volume:14
Number:2
Page Range:199-206
Date:2018
Official Publication:https://doi.org/10.1080/15548627.2017.1362525
PubMed:View item in PubMed

Repository Staff Only: item control page

Downloads

Downloads per month over past year

Open Access
MDC Library