Shedding light on ecDNA behavior using CRISPR-based live-cell imaging

Item Type:	Editorial
Title:	Shedding light on ecDNA behavior using CRISPR-based live-cell imaging
Creators Name:	Henssen, A.G.
Abstract:	Extrachromosomal oncogene amplification on extrachromosomal DNA (ecDNA) has emerged as a hallmark of many cancers. In this issue, Yi and colleagues developed a CRISPR-based method for imaging ecDNA in live cells, termed ecTag. Using ecTag, the authors reveal important features of ecDNA in cancer cells such as their random mitotic segregation and clustering into transcriptionally active hubs after mitosis.
Keywords:	Gene Amplification, Neoplasms, Oncogenes
Source:	Cancer Discovery
ISSN:	2159-8274
Publisher:	American Association for Cancer Research
Volume:	12
Number:	2
Page Range:	293-295
Date:	9 February 2022
Official Publication:	https://doi.org/10.1158/2159-8290.CD-21-1525
PubMed:	View item in PubMed

Repository Staff Only: item control page