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Formation and maintenance of the natural bypass vessels of the brain

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Item Type:Review
Title:Formation and maintenance of the natural bypass vessels of the brain
Creators Name:Perovic, T. and Harms, C. and Gerhardt, H.
Abstract:Ischemic diseases are the leading cause of death and disability worldwide. The main compensatory mechanism by which our body responds to reduced or blocked blood flow caused by ischemia is mediated by collateral vessels. Collaterals are present in many healthy tissues (including brain and heart) and serve as natural bypass vessels, by bridging adjacent arterial trees. This review focuses on: the definition and significance of pial collateral vessels, the described mechanism of pial collateral formation, an overview of molecular players and pathways involved in pial collateral biology and emerging approaches to prevent or mitigate risk factor-associated loss of pial collaterals. Despite their high clinical relevance and recent scientific efforts toward understanding collaterals, much of the fundamental biology of collaterals remains obscure.
Keywords:Collateral, Cerebrovasculature, Development, Maintenance, Ischemic Disease, Animals, Mice
Source:Frontiers in Cardiovascular Medicine
Publisher:Frontiers Media SA
Page Range:778773
Date:22 March 2022
Official Publication:https://doi.org/10.3389/fcvm.2022.778773
PubMed:View item in PubMed

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