Item Type: | Review |
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Title: | Cannabinoid receptor type 2 ligands: an analysis of granted patents since 2010 |
Creators Name: | Brennecke, B. and Gazzi, T. and Atz, K. and Fingerle, J. and Kuner, P. and Schindler, T. and de Weck, G. and Nazaré, M. and Grether, U. |
Abstract: | The G-protein-coupled cannabinoid receptor type 2 (CB(2)R) is a key element of the endocannabinoid (EC) system. EC/CB(2)R signaling has significant therapeutic potential in major pathologies affecting humans such as allergies, neurodegenerative disorders, inflammation or ocular diseases. CB(2)R agonism exerts anti-inflammatory and tissue protective effects in preclinical animal models of cardiovascular, gastrointestinal, liver, kidney, lung and neurodegenerative disorders. Existing ligands can be subdivided into endocannabinoids, cannabinoid-like and synthetic CB(2)R ligands that possess various degrees of potency on and selectivity against the cannabinoid receptor type 1. This review is an account of granted CB(2)R ligand patents from 2010 up to the present, which were surveyed using Derwent Innovation®. |
Keywords: | Agonist, Cannabinoid Receptor Type 1, Cannabinoid Receptor Type 2, Endocannabinoids, Endocannabinoid System, G Protein-Coupled Receptor, Animals |
Source: | Pharmaceutical Patent Analyst |
ISSN: | 2046-8954 |
Publisher: | Future Science |
Volume: | 10 |
Number: | 3 |
Page Range: | 111-163 |
Date: | May 2021 |
Official Publication: | https://doi.org/10.4155/ppa-2021-0002 |
PubMed: | View item in PubMed |
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