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Association and cosegregation of stroke with impaired edothelium-dependent vasorelaxation in stroke prone, spontaneously hypertensive rats

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Item Type:Article
Title:Association and cosegregation of stroke with impaired edothelium-dependent vasorelaxation in stroke prone, spontaneously hypertensive rats
Creators Name:Volpe, M. and Iaccarino, G. and Vecchione, C. and Rizzoni, D. and Russo, R. and Rubattu, S. and Condorelli, G. and Ganten, U. and Ganten, D. and Trimarco, B. and Lindpaintner, K.
Abstract:While hypertension is a major risk factor for stroke, it is not its sole determinant. Despite similar blood pressures, spontaneously hypertensive rats (SHR) do not share the predisposition to cerebrovascular disease typical of stroke-prone spontaneously hypertensive rats (SHRSP). We investigated vascular function in male SHR and SHRSP as well as in SHRSP/SHR-F2 hybrid animals. Animals were maintained on the appropriate dietary regimen necessary for the manifestation of stroke. Among the hybrid animals, a group of stroke-prone and a group of stroke-resistant rats were selected. Blood pressure was similar in all groups. Endothelium-independent vascular reactivity tested on isolated rings of thoracic aorta and basilar artery after death showed similar contractile and dilatory responses to serotonin and nitroglycerin, respectively, in all groups. In contrast, endothelium-dependent relaxation, in response to acetylcholine or substance P, was markedly reduced in SHRSP compared with SHR. Similarly, reduced vasodilatory responses were present in aortae of F2 rats that had suffered a stroke when compared with SHR or F2 rats resistant to stroke. The observed association and cosegregation of stroke with significant and specific impairment of endothelium-dependent vasorelaxation among SHRSP and stroke-prone F2 hybrids, respectively, suggest a potential causal role of altered endothelium-dependent vascular relaxation in the pathogenesis of stroke.
Keywords:Acetylcholine, Basilar Artery, Blood Pressure, Cerebrovascular Disorders, Disease Susceptibility, Genetic Crosses, Heart Rate, Hypertension, Muscle Contraction, Nitroglycerin, Nitroprusside, Serotonin, Substance P, Thoracic Aorta, Vascular Endothelium, Vascular Smooth Muscle, Vasodilation, Animals, Rats
Source:Journal of Clinical Investigation
ISSN:0021-9738
Publisher:American Society for Clinical Investigation (U.S.A.)
Volume:98
Number:2
Page Range:256-261
Date:15 July 1996
Official Publication:https://doi.org/10.1172/JCI118787
PubMed:View item in PubMed

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