Helmholtz Gemeinschaft

Search
Browse
Statistics
Feeds

Simultaneous T(2) and T(2)* mapping of multiple sclerosis lesions with radial RARE-EPI

[thumbnail of Original Article]
Preview
PDF (Original Article) - Requires a PDF viewer such as GSview, Xpdf or Adobe Acrobat Reader
4MB

Item Type:Article
Title:Simultaneous T(2) and T(2)* mapping of multiple sclerosis lesions with radial RARE-EPI
Creators Name:Herrmann, C., Els, A., Boehmert, L., Periquito, J., Eigentler, T.W., Millward, J., Waiczies, S., Kuchling, J., Paul, F. and Niendorf, T.
Abstract:PURPOSE: The characteristic MRI features of multiple sclerosis (MS) lesions make it conceptually appealing to pursue parametric mapping techniques that support simultaneous generation of quantitative maps of 2 or more MR contrast mechanisms. We present a modular rapid acquisition with relaxation enhancement (RARE)‐EPI hybrid that facilitates simultaneous T(2) and T(2)* mapping (2in1‐RARE‐EPI). METHODS: In 2in1‐RARE‐EPI the first echoes in the echo train are acquired with a RARE module, later echoes are acquired with an EPI module. To define the fraction of echoes covered by the RARE and EPI module, an error analysis of T(2) and T(2)* was conducted with Monte Carlo simulations. Radial k‐space (under)sampling was implemented for acceleration (R = 2). The feasibility of 2in1‐RARE‐EPI for simultaneous T(2) and T(2)* mapping was examined in a phantom study mimicking T(2) and T(2)* relaxation times of the brain. For validation, 2in1‐RARE‐EPI was benchmarked versus multi spin‐echo (MSE) and multi gradient‐echo (MGRE) techniques. The clinical applicability of 2in1‐RARE‐EPI was demonstrated in healthy subjects and MS patients. RESULTS: There was a good agreement between T(2)/T(2)* values derived from 2in1‐RARE‐EPI and T(2)/T(2)* reference values obtained from MSE and MGRE in both phantoms and healthy subjects. In patients, MS lesions in T(2) and T(2)* maps deduced from 2in1‐RARE‐EPI could be just as clearly delineated as in reference maps calculated from MSE/MGRE. CONCLUSION: This work demonstrates the feasibility of radially (under)sampled 2in1‐RARE‐EPI for simultaneous T(2) and T(2)* mapping in MS patients.
Keywords:Brain, EPI, MRI, Multiple Sclerosis, Parametric Mapping, Radial k-Space Sampling, RARE, Transversal Relaxation Time
Source:Magnetic Resonance in Medicine
ISSN:0740-3194
Publisher:Wiley
Volume:86
Number:3
Page Range:1383-1402
Date:September 2021
Official Publication:https://doi.org/10.1002/mrm.28811
PubMed:View item in PubMed

Repository Staff Only: item control page

Downloads

Downloads per month over past year

Open Access
MDC Library