Simple sugar and sugar-sweetened beverage intake during adolescence and risk of colorectal cancer precursors: adolescent sugar intake and colorectal polyp

Item Type:

Article

Title:

Creators Name:

Joh, H.K. and Lee, D.H. and Hur, J. and Nimptsch, K. and Chang, Y. and Joung, H. and Zhang, X. and Rezende, L.F.M. and Lee, J.E. and Ng, K. and Chen, Y. and Tabung, F.K. and Meyerhardt, J.A. and Chan, A.T. and Pischon, T. and Song, M. and Fuchs, C.S. and Willett, W.C. and Cao, Y. and Ogino, S. and Giovannucci, E. and Wu, K.

Abstract:

BACKGROUND & AIMS: Recent increasing trends in early-onset colorectal cancer (CRC) strongly supports that early-life diet is involved in CRC development. However, data are lacking on the relationship with high sugar intake during early-life. METHODS: We prospectively investigated the association of adolescent simple sugar (fructose, glucose, added sugar, total sugar) and sugar-sweetened beverage (SSB) intake with CRC precursor risk in 33,106 participants of the Nurses' Health Study II who provided adolescent dietary information in 1998 and subsequently underwent lower gastrointestinal endoscopy between 1999 and 2015. Odds ratios (ORs) and 95% confidence intervals (CIs) were estimated using logistic regression for clustered data. RESULTS: During follow-up, 2,909 conventional adenomas (758 high-risk) and 2,355 serrated lesions were identified (mean age at diagnoses, 52.2±4.3 years). High sugar and SSB intake during adolescence was positively associated with risk of adenoma, but not serrated lesions. Per each 5% increment in calorie/day of total fructose intake, multivariable ORs were 1.17 (95% CI 1.05-1.31) for total and 1.30 (95% CI 1.06-1.60) for high-risk adenoma. By subsite, ORs were 1.12 (95% CI 0.96-1.30) for proximal, 1.24 (95% CI 1.05-1.47) for distal, and 1.43 (95% CI 1.10-1.86) for rectal adenoma. Per 1 serving/day increment in SSB intake, ORs were 1.11 (95% CI 1.02-1.20) for total and 1.30 (95% CI 1.08-1.55) for rectal adenoma. Contrary to adolescent intake, sugar and SSB intake during adulthood was not associated with adenoma risk. CONCLUSIONS: High intake of simple sugars and SSBs during adolescence was associated with increased risk of conventional adenoma, especially rectal adenoma.

Keywords:

Colorectal Adenoma, Colorectal Polyp, Conventional Adenoma, Cancer Epidemiology, Fructose

Source:

Gastroenterology

ISSN:

0016-5085

Publisher:

Elsevier

Volume:

161

Number:

Page Range:

128-142

Date:

July 2021

Additional Information:

Official Publication:

https://doi.org/10.1053/j.gastro.2021.03.028

External Fulltext:

View full text on PubMed Central

PubMed:

View item in PubMed

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URL	URL Type
https://edoc.mdc-berlin.de/19724/	Preprint version

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