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| Item Type: | Article |
|---|---|
| Title: | Genetic deletion in uncoupling protein 3 augments (18)F-fluorodeoxyglucose cardiac uptake in the ischemic heart |
| Creators Name: | Gargiulo, S. and Petretta, M.P. and Greco, A. and Panico, M. and Larobina, M. and Gramanzini, M. and Schiattarella, G.G. and Esposito, G. and Petretta, M. and Brunetti, A. and Cuocolo, A. |
| Abstract: | BACKGROUND: We investigated the effects of uncoupling protein 3 (UCP3) genetic deletion on (18)F-fluorodeoxyglucose (FDG) cardiac uptake by positron emission tomography (PET)/computed tomography (CT) dedicated animal system after permanent coronary artery ligation. METHODS: Cardiac (18)F-FDG PET/CT was performed in UCP3 knockout (UCP3(-/-)) and wild-type (WT) mice one week after induction of myocardial infarction or sham procedure. RESULTS: In sham-operated mice no difference in left ventricular (LV) volume was detectable between WT and UCP3(-/-). After myocardial infarction, LV volume was higher in both WT and UCP3(-/-) compared to sham animals, with a significant interaction (p < 0.05) between genotype and myocardial infarction. In sham-operated animals no difference in FDG standardized uptake value (SUV) was detectable between WT (1.8 ± 0.6) and UCP3(-/-) (1.8 ± 0.6). After myocardial infarction SUV was significantly higher in remote areas than in infarcted territories in both UCP3(-/-) and WT mice (both p < 0.01). Moreover, in remote areas, SUV was significantly higher (p < 0.001) in UCP3(-/-) as compared to WT, while in the infarcted territory SUV was comparable (p = 0.29). A significant relationship (r = 0.68, p < 0.001) between LV volume and SUV was found. CONCLUSIONS: In a mice model of permanent coronary occlusion, UCP3 deficiency results in a metabolic shift that favored glycolytic metabolism and increased FDG uptake in remote areas. |
| Keywords: | Uncoupling Protein, Myocardial Infarction, Glucose Metabolism, Positron Emission Tomography, Animals, Mice |
| Source: | BMC Cardiovascular Disorders |
| ISSN: | 1471-2261 |
| Publisher: | BioMed Central |
| Volume: | 14 |
| Page Range: | 98 |
| Date: | 8 August 2014 |
| Official Publication: | https://doi.org/10.1186/1471-2261-14-98 |
| PubMed: | View item in PubMed |
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