Epigenetic modulation of vascular diseases: assessing the evidence and exploring the opportunities

Item Type:	Review
Title:	Epigenetic modulation of vascular diseases: assessing the evidence and exploring the opportunities
Creators Name:	Schiattarella, G.G. and Madonna, R. and Van Linthout, S. and Thum, T. and Schulz, R. and Ferdinandy, P. and Perrino, C.
Abstract:	Vascular adaptations to either physiological or pathophysiological conditions commonly require gene expression modifications in the most represented cellular elements of the vessel wall, i.e. endothelial and smooth muscle cells. In addition to transcription factors, a number of mechanisms contribute to the regulation of gene expression in these cells including noncoding RNAs, histone and DNA modifications, collectively indicated as epigenetic modifications. Here, we summarize the state of art regarding the role of epigenetic changes in major vascular diseases, and discuss the potential diagnostic and therapeutic applications of epigenetic modulation in this context.
Keywords:	Epigenetics, Cardiovascular Diseases, Endothelial Cells, Smooth Muscle Cells, Animals, Mice
Source:	Vascular Pharmacology
ISSN:	1537-1891
Publisher:	Elsevier
Volume:	107
Page Range:	43-52
Date:	August 2018
Official Publication:	https://doi.org/10.1016/j.vph.2018.02.009
PubMed:	View item in PubMed

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