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Lineage commitment of hematopoietic stem cells and progenitors: insights from recent single cell and lineage tracing technologies

Item Type:Article
Title:Lineage commitment of hematopoietic stem cells and progenitors: insights from recent single cell and lineage tracing technologies
Creators Name:Loughran, S.J. and Haas, S. and Wilkinson, A.C. and Klein, A.M. and Brand, M.
Abstract:Blood production is essential to maintain human health, and even small perturbations in hematopoiesis can cause disease. Hematopoiesis has therefore been the focus of much research for many years. Experiments determining the lineage potentials of hematopoietic stem and progenitor cells (HSPCs) in vitro and after transplantation revealed a hierarchy of progenitor cell states, where differentiating cells undergo lineage commitment—a series of irreversible changes that progressively restrict their potential. New technologies have recently been developed that allow for a more detailed analysis of the molecular states and fates of differentiating HSPCs. Proteomic and lineage-tracing approaches, alongside single-cell transcriptomic analyses, have recently helped to reveal the biological complexity underlying lineage commitment during hematopoiesis. Recent insights from these new technologies were presented by Dr. Marjorie Brand and Dr. Allon Klein in the Summer 2019 ISEH Webinar, and are discussed in this Perspective.
Keywords:Cell Differentiation, Cell Lineage, Cell Tracking, Hematopoietic Stem Cells, Proteomics, Animals
Source:Experimental Hematology
ISSN:0301-472X
Publisher:Elsevier
Volume:88
Page Range:1-6
Date:August 2020
Official Publication:https://doi.org/10.1016/j.exphem.2020.07.002
PubMed:View item in PubMed

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