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High expression level of alpha6 integrin in human breast carcinoma is correlated with reduced survival

Item Type:Article
Title:High expression level of alpha6 integrin in human breast carcinoma is correlated with reduced survival
Creators Name:Friedrichs, K. and Ruiz, P. and Franke, F. and Gille, I. and Terpe, H.J. and Imhof, B.A.
Abstract:We recently reported that alpha 6 integrin mediates experimental metastasis in mice by functioning in the adhesion of tumor cells to the vascular endothelium. In the current study, we investigated the expression of human alpha 6 integrin in invasive breast carcinomas of 119 women. In 50% of the tumors alpha 6 integrin was expressed in the majority of the cells, and this expression was correlated with reduced survival time. By contrast, the 24% of patients with breast tumors devoid of alpha 6 integrin expression all survived. The tumors were also evaluated for clinical risk factors including histological grading and steroid receptor level. The combination of these factors with alpha 6 integrin expression was superior in predicting overall survival than considering the other factors alone. The correlation with decreased survival time was consistent, regardless of whether the tumors expressed the alpha 6 integrin A or B forms, which differ in their cytoplasmic domain. On the basis of this pilot study we consider alpha 6 integrin expression to be a novel prognostic marker for human breast cancer.
Keywords:Base Sequence, Breast Neoplasms, Immunohistochemistry, Integrin alpha6, Isomerism, Molecular Sequence Data, Polymerase Chain Reaction, Predictive Value of Tests, Prognosis, Reference Values, Risk Factors, Survival Analysis, Animals, Rats
Source:Cancer Research
ISSN:0008-5472
Publisher:American Association for Cancer Research (U.S.A.)
Volume:55
Number:4
Page Range:901-906
Date:15 February 1995
Official Publication:http://cancerres.aacrjournals.org/content/55/4/901.abstract
PubMed:View item in PubMed

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