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| Item Type: | Preprint | ||||
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| Title: | Diffusion pseudotime robustly reconstructs lineage branching | ||||
| Creators Name: | Haghverdi, L. and Büttner, M. and Wolf, F. A. and Buettner, F. and Theis, F.J. | ||||
| Abstract: | Single-cell gene expression profiles of differentiating cells encode their intrinsic latent temporal order. We describe an efficient way to robustly estimate this order according to a diffusion pseudotime, which measures transitions on all length scales between cells using diffusion-like random walks. This allows us to identify cells that undergo branching decisions or are in metastable states, and thereby genes differentially regulated at these states. | ||||
| Source: | bioRxiv | ||||
| Title of Book: | Diffusion pseudotime robustly reconstructs lineage branching | ||||
| Publisher: | Cold Spring Harbor Laboratory Press | ||||
| Article Number: | 041384 | ||||
| Date: | 2 March 2016 | ||||
| Official Publication: | https://doi.org/10.1101/041384 | ||||
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