Prognostic impact of Claudin 18.2 in gastric and esophageal adenocarcinomas

Arnold, A.; Daum, S.; von Winterfeld, M.; Berg, E.; Hummel, M.; Rau, B.; Stein, U.; Treese, C.

Prognostic impact of Claudin 18.2 in gastric and esophageal adenocarcinomas

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Item Type:	Article
Title:	Prognostic impact of Claudin 18.2 in gastric and esophageal adenocarcinomas
Creators Name:	Arnold, A., Daum, S., von Winterfeld, M., Berg, E., Hummel, M., Rau, B., Stein, U. and Treese, C.
Abstract:	INTRODUCTION: The tight junction molecule Claudin 18.2 is selectively expressed in healthy and malignant gastric epithelial tissue and is a promising therapy target for high Claudin 18.2 expressing adenocarcinomas of the esophagogastric junction and stomach (AEG/S). METHODS: This study analyzed the prevalence, characteristics and prognostic impact of Claudin 18.2 expression in primary tumor, lymph node and distant metastasis in a large Caucasian AGE/S cohort with 414 patients. RESULTS: Claudin 18.2 was highly expressed in 17.1% of primary tumors, 26.7% of lymph node metastasis and 16.7% of distant metastasis. High Claudin 18.2 expression in lymph node metastasis and primary tumors correlated significantly (p < 0.001). High expression of Claudin 18.2 was neither associated with histomorphogical subtype, or tumor state, nor with overall survival. CONCLUSION: In Caucasian AEG/S patients, 17.1% appeared to be eligible for an anti-Claudin 18.2 therapy. Claudin 18.2 expression itself has no impact on prognosis and is not related to any tumor subtype.
Keywords:	Claudin 18.2, Claudiximab, IMAB362, Gastric Cancer, Esophageal Cancer
Source:	Clinical and Translational Oncology
ISSN:	1699-048X
Publisher:	Springer
Volume:	22
Number:	12
Page Range:	2357-2363
Date:	December 2020
Official Publication:	https://doi.org/10.1007/s12094-020-02380-0
PubMed:	View item in PubMed

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