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A connectome of the adult drosophila central brain

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Item Type:Preprint
Title:A connectome of the adult drosophila central brain
Creators Name:Xu, C.S. and Januszewski, M. and Lu, Z. and Takemura, S. and Hayworth, K.J. and Huang, G. and Shinomiya, K. and Maitin-Shepard, J. and Ackerman, D. and Berg, S. and Blakely, T. and Bogovic, J. and Clements, J. and Dolafi, T. and Hubbard, P. and Kainmueller, D. and Katz, W. and Kawase, T. and Khairy, K.A. and Leavitt, L. and Li, P.H. and Lindsey, L. and Neubarth, N. and Olbris, D.J. and Otsuna, H. and Troutman, E.T. and Umayam, L. and Zhao, T. and Ito, M. and Goldammer, J. and Wolff, T. and Svirskas, R. and Schlegel, P. and Neace, E.R. and Knecht, C.J. and Alvarado, C.X. and Bailey, D.A. and Ballinger, S. and Borycz, J.A. and Canino, B.S. and Cheatham, N. and Cook, M. and Dreher, M. and Duclos, O. and Eubanks, B. and Fairbanks, K. and Finley, S. and Forknall, N. and Francis, A. and Hopkins, G.P. and Joyce, E.M. and Kim, S.J. and Kirk, N.A. and Kovalyak, J. and Lauchie, S.A. and Lohff, A. and Maldonado, C. and Manley, E.A. and McLin, S. and Mooney, C. and Ndama, M. and Ogundeyi, O. and Okeoma, N. and Ordish, C. and Padilla, N. and Patrick, C. and Paterson, T. and Phillips, E.E. and Phillips, E.M. and Rampally, N. and Ribeiro, C. and Robertson, M.K. and Rymer, J.T. and Ryan, S.M. and Sammons, M. and Scott, A.K. and Scott, A.L. and Shinomiya, A. and Smith, C. and Smith, K. and Smith, N.L. and Sobeski, M.A. and Suleiman, A. and Swift, J. and Takemura, S. and Talebi, I. and Tarnogorska, D. and Tenshaw, E. and Tokhi, T. and Walsh, J.J. and Yang, T. and Horne, J.A. and Li, F. and Parekh, R. and Rivlin, P.K. and Jayaraman, V. and Ito, K. and Saalfeld, S. and George, R. and Meinertzhagen, I. and Rubin, G.M. and Hess, H.F. and Scheffer, L.K. and Jain, V. and Plaza, S.M.
Abstract:The neural circuits responsible for behavior remain largely unknown. Previous efforts have reconstructed the complete circuits of small animals, with hundreds of neurons, and selected circuits for larger animals. Here we (the FlyEM project at Janelia and collaborators at Google) summarize new methods and present the complete circuitry of a large fraction of the brain of a much more complex animal, the fruit fly Drosophila melanogaster. Improved methods include new procedures to prepare, image, align, segment, find synapses, and proofread such large data sets; new methods that define cell types based on connectivity in addition to morphology; and new methods to simplify access to a large and evolving data set. From the resulting data we derive a better definition of computational compartments and their connections; an exhaustive atlas of cell examples and types, many of them novel; detailed circuits for most of the central brain; and exploration of the statistics and structure of different brain compartments, and the brain as a whole. We make the data public, with a web site and resources specifically designed to make it easy to explore, for all levels of expertise from the expert to the merely curious. The public availability of these data, and the simplified means to access it, dramatically reduces the effort needed to answer typical circuit questions, such as the identity of upstream and downstream neural partners, the circuitry of brain regions, and to link the neurons defined by our analysis with genetic reagents that can be used to study their functions. Note: In the next few weeks, we will release a series of papers with more involved discussions. One paper will detail the hemibrain reconstruction with more extensive analysis and interpretation made possible by this dense connectome. Another paper will explore the central complex, a brain region involved in navigation, motor control, and sleep. A final paper will present insights from the mushroom body, a center of multimodal associative learning in the fly brain.
Source:bioRxiv
Publisher:Cold Spring Harbor Laboratory Press
Article Number:2020.01.21.911859
Date:21 January 2020
Official Publication:https://doi.org/10.1101/2020.01.21.911859

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