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Circuit-specific dendritic development in the piriform cortex

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Item Type:Preprint
Title:Circuit-specific dendritic development in the piriform cortex
Creators Name:Moreno-Velasquez, L. and Kaehne, M. and Lo, H. and Lenzi, S. and Breustedt, J. and Schmitz, D. and Rüdiger, S. and Johenning, F.W.
Abstract:Dendritic geometry is largely determined during postnatal development and has a substantial impact on neural function. In sensory processing, postnatal development of the dendritic tree is affected by two dominant circuit motifs, ascending sensory feedforward inputs and descending and local recurrent connections. Two subtypes of layer 2 neurons in the three-layered anterior piriform cortex, layer 2a and layer 2b neurons, display a clear vertical segregation of these two circuit motifs. Here, we combined electrophysiology, detailed morphometry and Ca(2+) imaging-both of neuronal networks as well as of subcellular structures-in acute mouse brain slices and modeling. This allowed us to compare the functional implications of distinct circuit-specific postnatal dendritic growth patterns in these two neuronal subtypes. We observed that determination of branching complexity, dendritic length increases and pruning occurred in distinct growth phases. Layer 2a and layer 2b neurons displayed growth phase specific developmental differences between their apical and basal dendritic trees. This was reflected by compartment-specific differences in Ca(2+) signaling. The morphological and functional developmental pattern differences between layer 2a and layer 2b neurons dendrites provide further evidence that they constitute two functionally distinct streams of olfactory information processing.
Keywords:Piriform Cortex, Brain Development, Dendrites, Calcium Signaling
Publisher:Cold Spring Harbor Laboratory Press
Article Number:868075
Date:8 December 2019
Official Publication:https://doi.org/10.1101/868075
Related to:
https://edoc.mdc-berlin.de/18985/Final version

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