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| Item Type: | Article |
|---|---|
| Title: | Increased expression of endothelial constitutive nitric oxide synthase in rat aorta during pregnancy |
| Creators Name: | Goetz, R.M., Morano, I., Calovini, T., Studer, R. and Holtz, J. |
| Abstract: | The mechanisms underlying enhanced vascular reactivity in pregnancy are not yet defined. In this study we have investigated the potential role of endothelium-derived vasodilator nitric oxide (EDNO). EDNO-mediated dilatory responses in vitro were markedly increased in aorta of pregnant as compared with nonpregnant rats. This increase in EDNO-releasability was accompanied by a two-fold increase in mRNA of endothelial constitutive nitric oxide synthase (NOS-III). Chronically substituted estrogen, but neither progesterone nor testosterone induced an upregulation of NOS-III mRNA in aorta of gonadectomized rats which amounted to about half that induced in aorta of pregnant rats. Thus, increased EDNO-releasability and increased NOS-III mRNA contribute to enhanced vascular reactivity in pregnancy. |
| Keywords: | Amino Acid Oxidoreductases, Aorta, Base Sequence, Vascular Endothelium, Estradiol, Enzymologic Gene Expression Regulation, Molecular Sequence Data, Nitric Oxide, Nitric Oxide Synthase, Oligodeoxyribonucleotides, Pregnancy, Messenger RNA, Up-Regulation, Animals, Rats |
| Source: | Biochemical and Biophysical Research Communications |
| ISSN: | 0006-291X |
| Publisher: | Academic Press |
| Volume: | 205 |
| Number: | 1 |
| Page Range: | 905-910 |
| Date: | 30 November 1994 |
| Official Publication: | https://doi.org/10.1006/bbrc.1994.2750 |
| PubMed: | View item in PubMed |
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