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Janggu: deep learning for genomics

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Item Type:Preprint
Title:Janggu: deep learning for genomics
Creators Name:Kopp, W. and Monti, R. and Tamburrini, A. and Ohler, U. and Akalin, A.
Abstract:MOTIVATION: In recent years, numerous applications have demonstrated the potential of deep learning for an improved understanding of biological processes. However, most deep learning tools developed so far are designed to address a specific question on a fixed dataset and/or by a fixed model architecture. Adapting these models to integrate new datasets or to address different hypotheses can lead to considerable software engineering effort. To address this aspect we have built Janggu, a python library that facilitates deep learning for genomics applications. RESULTS: Janggu aims to ease data acquisition and model evaluation in multiple ways. Among its key features are special dataset objects, which form a unified and flexible data acquisition and pre-processing framework for genomics data that enables streamlining of future research applications through reusable components. Through a numpy-like interface, the dataset objects are directly compatible with popular deep learning libraries, including keras. Furthermore, Janggu offers the possibility to visualize predictions as genomic tracks or by exporting them to the BIGWIG format. We illustrate the functionality of Janggu on several deep learning genomics applications. First, we evaluate different model topologies for the task of predicting binding sites for the transcription factor JunD. Second, we demonstrate the framework on published models for predicting chromatin effects. Third, we show that promoter usage measured by CAGE can be predicted using DNase hyper-sensitivity, histone modifications and DNA sequence features. We improve the performance of these models due to a novel feature in Janggu that allows us to include high-order sequence features. We believe that Janggu will help to significantly reduce repetitive programming overhead for deep learning applications in genomics, while at the same time enabling computational biologists to assess biological hypotheses more rapidly. AVAILABILITY: Janggu is freely available under a GPL-v3 license on https://github.com/BIMSBbioinfo/janggu or via https://pypi.org/project/janggu
Keywords:Deep Learning, Machine Learning, Genomics, Epigenomics
Source:bioRxiv
Publisher:Cold Spring Harbor Laboratory Press (U.S.A)
Article Number:700450
Date:16 July 2019
Official Publication:https://doi.org/10.1101/700450

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