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| Item Type: | Article |
|---|---|
| Title: | Size matters: grey matter brain reserve predicts executive functioning in the elderly |
| Creators Name: | Laubach, M., Lammers, F., Zacharias, N., Feinkohl, I., Pischon, T., Borchers, F, Slooter, A.J.C., Kühn, S., Spies, C. and Winterer, G. |
| Abstract: | Preserved executive functioning (EF) is crucial for daily functioning in the elderly and it appears to predict dementia development. We sought to clarify the role of atrophy-corrected cortical grey matter (GM) volume as a potential brain reserve (BR) marker for EF in the elderly. In total, 206 pre-surgical subjects (72.50 ± 4.95 years; mean MMSE score 28.50) were investigated. EF was primarily assessed using the Trail Making Test B (TMT B). Global/ lobar GM volumes were acquired with T1 MP-RAGE. Adjusting for key covariates including a brain atrophy index (i.e. brain parenchymal fraction), multiple linear regression analysis was used to study associations of GM volumes and TMT B. All GM volumes - most notably of global GM - were significantly associated with TMT B independently of GM atrophy (ß = -0.201 to -0.275, p = 0.001 to 0.012). Using atrophy-corrected GM volume as an estimate of maximal GM size in youth may serve as a BR predictor for cognitive decline in future studies investigating BR in the elderly. |
| Keywords: | Executive Functioning, Neuroimaging, Elderly, Neuropsychology, Brain Reserve, Cognitive Reserve |
| Source: | Neuropsychologia |
| ISSN: | 0028-3932 |
| Publisher: | Elsevier / Pergamon |
| Volume: | 119 |
| Page Range: | 172-181 |
| Date: | October 2018 |
| Official Publication: | https://doi.org/10.1016/j.neuropsychologia.2018.08.008 |
| PubMed: | View item in PubMed |
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