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Evolutionary plasticity in the innate immune function of Akirin

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Item Type:Preprint
Title:Evolutionary plasticity in the innate immune function of Akirin
Creators Name:Polanowska, J. and Chen, J.X. and Soule, J. and Omi, S. and Belougne, J. and Taffoni, C. and Pujol, N. and Selbach, M. and Zugasti, O. and Ewbank, J.J.
Abstract:Eukaryotic gene expression requires the coordinated action of transcription factors, chromatin remodelling complexes and RNA polymerase. The conserved nuclear protein Akirin plays a central role in immune gene expression in insects and mammals, linking the SWI/SNF chromatin-remodelling complex with the transcription factor NF{kappa}B. Although nematodes lack NF{kappa}B, Akirin is also indispensable for the expression of defence genes in the epidermis of Caenorhabditis elegans following natural fungal infection. Through a combination of reverse genetics and biochemistry, we discovered that in C. elegans Akirin has conserved its role of bridging chromatin-remodellers and transcription factors, but that the identity of its functional partners is different since it forms a physical complex with NuRD proteins and the POU-class transcription factor CEH-18. In addition to providing a substantial step forward in our understanding of innate immune gene regulation in C. elegans, our results give insight into the molecular evolution of lineage-specific signalling pathways.
Keywords:Antimicrobial Peptide, Chromatin Remodelling, Gene Expression, Innate Immunity, Signal Transduction
Source:bioRxiv
Publisher:Cold Spring Harbor Laboratory (U.S.A.)
Article Number:230102
Date:6 December 2017
Official Publication:https://doi.org/10.1101/230102
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https://edoc.mdc-berlin.de/17615/Final version

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