Helmholtz Gemeinschaft

Search
Browse
Statistics
Feeds

Defective synapse maturation and enhanced synaptic plasticity in Shank2(-/-) mice

[img]
Preview
PDF - Requires a PDF viewer such as GSview, Xpdf or Adobe Acrobat Reader
593kB
Item Type:Preprint
Title:Defective synapse maturation and enhanced synaptic plasticity in Shank2(-/-) mice
Creators Name:Wegener, S. and Buschler, A. and Stempel, A.V. and Shoichet, S.A. and Manahan-Vaughan, D. and Schmitz, D.
Abstract:Autism spectrum disorders (ASDs) are neurodevelopmental disorders with a strong genetic aetiology. Since mutations in human SHANK genes have been found in patients with autism, genetic mouse models are employed for a mechanistic understanding of ASDs and the development of therapeutic strategies. In sharp contrast to all studies so far on the function of SHANK proteins, we observe enhanced synaptic plasticity in Shank2(-/-) mice, under various conditions in vitro and in vivo. Reproducing and extending previous results, we here present a plausible mechanistic explanation for the mutants' increased capacity for long-term potentiation (LTP) by describing a synaptic maturation deficit in Shank2(-/-) mice.
Source:bioRxiv
Publisher:Cold Spring Harbor Laboratory (U.S.A.)
Article Number:193078
Date:29 September 2017
Official Publication:https://doi.org/10.1101/193078
Related to:
URLURL Type
http://edoc.mdc-berlin.de/17602/Final version

Repository Staff Only: item control page

Downloads

Downloads per month over past year

Open Access
MDC Library