Item Type: | Preprint |
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Title: | G-quadruplex prediction in E.coli genome reveals a conserved putative G-quadruplex-hairpin-duplex switch |
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Creators Name: | Doluca, O. and Kaplan, O.I. and Berber, B. and Hekim, N. |
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Abstract: | Many studies show that short non-coding sequences are widely conserved among regulatory elements. More and more conserved sequences are being discovered since the development next generation sequencing technology. A common approach to identify conserved sequences with regulatory roles rely on the topological change such as hairpin formation on the DNA or RNA level. However G quadruplexes, a non-canonical nucleic acid topology with little established biological role, is rarely considered for conserved regulatory element discovery. Here we present the use of G-quadruplex prediction algorithm to identify putative G-quadruplex-forming and conserved elements in E.coli genome. Phylogenetic analysis of 52 G-quadruplex forming sequences revealed two conserved G-quadruplex motifs with potential regulatory role. |
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Source: | bioRxiv |
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Publisher: | Cold Spring Harbor Laboratory Press |
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Article Number: | 032615 |
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Date: | 24 November 2015 |
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Official Publication: | https://doi.org/10.1101/032615 |
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Related to: | |
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