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G-quadruplex prediction in E.coli genome reveals a conserved putative G-quadruplex-hairpin-duplex switch

Item Type:Preprint
Title:G-quadruplex prediction in E.coli genome reveals a conserved putative G-quadruplex-hairpin-duplex switch
Creators Name:Doluca, O. and Kaplan, O.I. and Berber, B. and Hekim, N.
Abstract:Many studies show that short non-coding sequences are widely conserved among regulatory elements. More and more conserved sequences are being discovered since the development next generation sequencing technology. A common approach to identify conserved sequences with regulatory roles rely on the topological change such as hairpin formation on the DNA or RNA level. However G quadruplexes, a non-canonical nucleic acid topology with little established biological role, is rarely considered for conserved regulatory element discovery. Here we present the use of G-quadruplex prediction algorithm to identify putative G-quadruplex-forming and conserved elements in E.coli genome. Phylogenetic analysis of 52 G-quadruplex forming sequences revealed two conserved G-quadruplex motifs with potential regulatory role.
Source:bioRxiv
Publisher:Cold Spring Harbor Laboratory (U.S.A.)
Article Number:032615
Date:24 November 2015
Official Publication:https://doi.org/10.1101/032615
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http://edoc.mdc-berlin.de/15991/Final version

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