![[feed]](/style/images/feed-icon-14x14.png){kind=icon}
Tools
Tools
Preview |
PDF
- Requires a PDF viewer such as GSview, Xpdf or Adobe Acrobat Reader
1MB |
| Item Type: | Review |
|---|---|
| Title: | Role of vitamin A/retinoic acid in regulation of embryonic and adult hematopoiesis |
| Creators Name: | Canete, A., Cano, E., Munoz-Chapuli, R. and Carmona, R. |
| Abstract: | Vitamin A is an essential micronutrient throughout life. Its physiologically active metabolite retinoic acid (RA), acting through nuclear retinoic acid receptors (RARs), is a potent regulator of patterning during embryonic development, as well as being necessary for adult tissue homeostasis. Vitamin A deficiency during pregnancy increases risk of maternal night blindness and anemia and may be a cause of congenital malformations. Childhood Vitamin A deficiency can cause xerophthalmia, lower resistance to infection and increased risk of mortality. RA signaling appears to be essential for expression of genes involved in developmental hematopoiesis, regulating the endothelial/blood cells balance in the yolk sac, promoting the hemogenic program in the aorta-gonad-mesonephros area and stimulating eryrthropoiesis in fetal liver by activating the expression of erythropoietin. In adults, RA signaling regulates differentiation of granulocytes and enhances erythropoiesis. Vitamin A may facilitate iron absorption and metabolism to prevent anemia and plays a key role in mucosal immune responses, modulating the function of regulatory T cells. Furthermore, defective RA/RAR{alpha} signaling is involved in the pathogenesis of acute promyelocytic leukemia due to a failure in differentiation of promyelocytes. This review focuses on the different roles played by vitamin A/RA signaling in physiological and pathological mouse hematopoiesis duddurring both, embryonic and adult life, and the consequences of vitamin A deficiency for the blood system. |
| Keywords: | Vitamin A, Retinoic Acid, Hematopoiesis, Embryos, Leukemia, Vitamin A Deficiency, Animals |
| Source: | Nutrients |
| ISSN: | 2072-6643 |
| Publisher: | MDPI |
| Volume: | 9 |
| Number: | 2 |
| Page Range: | 159 |
| Date: | 20 February 2017 |
| Official Publication: | https://doi.org/10.3390/nu9020159 |
| PubMed: | View item in PubMed |
Repository Staff Only: item control page
