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| Item Type: | Article |
|---|---|
| Title: | Hypoxia-inducible factor-1α inhibition modulates airway hyperresponsiveness and nitric oxide levels in a BALB/c mouse model of asthma |
| Creators Name: | Dewitz, C., McEachern, E., Shin, S., Akong, K., Nagle, D.G., Broide, D.H., Akuthota, P. and Crotty Alexander, L.E. |
| Abstract: | Hypoxia inducible factor (HIF)-1α is a master regulator of inflammation and is upregulated in alveolar macrophages and lung parenchyma in asthma. HIF-1α regulates select pathways in allergic inflammation, and thus may drive particular asthma phenotypes. This work examines the role of pharmacologic HIF-1α inhibition in allergic inflammatory airway disease (AIAD) pathogenesis in BALB/c mice, which develop an airway hyperresponsiveness (AHR) asthma phenotype. Systemic treatment with HIF-1α antagonist YC-1 suppressed the increase in HIF-1α expression seen in control AIAD mice. Treatment with YC-1 also decreased AHR, blood eosinophilia, and allergic inflammatory gene expression: IL-5, IL-13, myeloperoxidase and iNOS. AIAD mice had elevated BAL levels of NO, and treatment with YC-1 eliminated this response. However, YC-1 did not decrease BAL, lung or bone marrow eosinophilia. We conclude that HIF-1α inhibition in different genetic backgrounds, and thus different AIAD phenotypes, decreases airway resistance and markers of inflammation in a background specific manner. |
| Keywords: | Hypoxia Inducible Factor (HIF)-1α, Asthma, Allergic Inflammation, Easoinophils, Nitric Oxide, YC-1, Animals, Mice |
| Source: | Clinical Immunology |
| ISSN: | 1521-6616 |
| Publisher: | Elsevier / Academic Press |
| Volume: | 176 |
| Page Range: | 94-99 |
| Date: | March 2017 |
| Official Publication: | https://doi.org/10.1016/j.clim.2017.01.002 |
| PubMed: | View item in PubMed |
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