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Neuregulin/ErbB signaling in developmental myelin formation and nerve repair

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Item Type:Review
Title:Neuregulin/ErbB signaling in developmental myelin formation and nerve repair
Creators Name:Birchmeier, C. and Bennett, D.L.H.
Abstract:Myelin is essential for rapid and accurate conduction of electrical impulses by axons in the central and peripheral nervous system (PNS). Myelin is formed in the early postnatal period, and developmental myelination in the PNS depends on axonal signals provided by Nrg1/ErbB receptors. In addition, Nrg1 is required for effective nerve repair and remyelination in adulthood. We discuss here similarities and differences in Nrg1/ErbB functions in developmental myelination and remyelination after nerve injury.
Keywords:Myelination, Remyelination, Peripheral Nervous System, Nrg1, Animals
Source:Current Topics in Developmental Biology
Series Name:Current Topics in Developmental Biology
Title of Book:Essays on Developmental Biology, Part A
ISSN:0070-2153
ISBN:978-0-12-802956-5
Publisher:Elsevier (U.S.A.)
Volume:116
Page Range:45-64
Number of Pages:744
Date:2016
Official Publication:https://doi.org/10.1016/bs.ctdb.2015.11.009
PubMed:View item in PubMed

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