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| Item Type: | Article |
|---|---|
| Title: | The B-cell antigen receptor integrates adaptive and innate immune signals |
| Creators Name: | Otipoby, K.L., Waisman, A., Derudder, E., Srinivasan, L., Franklin, A. and Rajewsky, K. |
| Abstract: | B cells respond to antigens by engagement of their B-cell antigen receptor (BCR) and of coreceptors through which signals from helper T cells or pathogen-associated molecular patterns are delivered. We show that the proliferative response of B cells to the latter stimuli is controlled by BCR-dependent activation of phosphoinositidyl 3-kinase (PI-3K) signaling. Glycogen synthase kinase 3{beta} and Foxo1 are two PI-3K-regulated targets that play important roles, but to different extents, depending on the specific mitogen. These results suggest a model for integrating signals from the innate and the adaptive immune systems in the control of the B-cell immune response. |
| Keywords: | BCR, B-Cell Proliferation, PI-3K, GSK3{beta}, Foxo1, Animals, Mice |
| Source: | Proceedings of the National Academy of Sciences of the United States of America |
| ISSN: | 0027-8424 |
| Publisher: | National Academy of Sciences |
| Volume: | 112 |
| Number: | 39 |
| Page Range: | 12145-12150 |
| Date: | 29 September 2015 |
| Official Publication: | https://doi.org/10.1073/pnas.1516428112 |
| PubMed: | View item in PubMed |
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