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| Item Type: | Article |
|---|---|
| Title: | Blood flow and Bmp signaling control endocardial chamber morphogenesis |
| Creators Name: | Dietrich, A.C., Lombardo, V.A., Veerkamp, J., Priller, F. and Abdelilah-Seyfried, S. |
| Abstract: | During heart development, the onset of heartbeat and blood flow coincides with a ballooning of the cardiac chambers. Here, we have used the zebrafish as a vertebrate model to characterize chamber ballooning morphogenesis of the endocardium, a specialized population of endothelial cells that line the interior of the heart. By combining functional manipulations, fate mapping studies, and high-resolution imaging, we show that endocardial growth occurs without an influx of external cells. Instead, endocardial cell proliferation is regulated, both by blood flow and by Bmp signaling, in a manner independent of vascular endothelial growth factor (VEGF) signaling. Similar to myocardial cells, endocardial cells obtain distinct chamber-specific and inner- versus outer-curvature-specific surface area sizes. We find that the hemodynamic-sensitive transcription factor Klf2a is involved in regulating endocardial cell morphology. These findings establish the endocardium as the flow-sensitive tissue in the heart with a key role in adapting chamber growth in response to the mechanical stimulus of blood flow. |
| Keywords: | Bone Morphogenetic Proteins, Cell Movement, Cell Proliferation, Endocardium, Endothelial Cells, Hemodynamics, Kruppel-Like Transcription Factors, Morphogenesis, Signal Transduction, Vascular Endothelial Growth Factor A, Zebrafish Proteins, Animals, Zebrafish |
| Source: | Developmental Cell |
| ISSN: | 1534-5807 |
| Publisher: | Cell Press |
| Volume: | 30 |
| Number: | 4 |
| Page Range: | 367-377 |
| Date: | 25 August 2014 |
| Additional Information: | Erratum in: Dev Cell 32(3): 387. |
| Official Publication: | https://doi.org/10.1016/j.devcel.2014.06.020 |
| PubMed: | View item in PubMed |
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