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A method for the generation of TCR retrogenic mice

Item Type:Article
Title:A method for the generation of TCR retrogenic mice
Creators Name:Kieback, E. and Hilgenberg, E. and Fillatreau, S.
Abstract:Retrogenic mice provide a unique system for rapidly analyzing the function of genes in the hematopoietic system. Here, we provide a detailed protocol for the production of retrogenic mice expressing genes coding for T cell receptor (TCR) for antigen. This technology should be easy to establish in any laboratory and should allow for a rapid progress in our understanding of the functional roles of TCR repertoires in immunity.
Keywords:T Cell Receptor for Antigen (TCR), Retrogenic Mice, Retrovirus, Transduction, Transfection, Animals, Mice
Source:Methods in Molecular Biology
Series Name:Methods in Molecular Biology
Title of Book:T-helper cells : methods and protocols
ISSN:1064-3745
ISBN:978-1-4939-1211-7
Publisher:Springer / Humana Press (U.S.A.)
Volume:1193
Page Range:117-126
Date:2014
Official Publication:https://doi.org/10.1007/978-1-4939-1212-4_12
PubMed:View item in PubMed

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