Multiple sclerosis: The elevated antibody response to Epstein-Barr virus primarily targets, but is not confined to, the glycine-alanine repeat of Epstein-Barr nuclear antigen-1

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Item Type:	Article
Title:	Multiple sclerosis: The elevated antibody response to Epstein-Barr virus primarily targets, but is not confined to, the glycine-alanine repeat of Epstein-Barr nuclear antigen-1
Creators Name:	Ruprecht, K., Wunderlich, B., Gieß, R., Meyer, P., Loebel, M., Lenz, K., Hofmann, J., Rosche, B., Wengert, O., Paul, F., Reimer, U. and Scheibenbogen, C.
Abstract:	Patients with multiple sclerosis (MS) have elevated antibodies against Epstein-Barr virus (EBV), but data on the epitope-resolved specificity of these antibodies are scarce. Using a peptide microarray containing 1465 peptides representing 8 full-length EBV proteins, we identified higher (p<0.001) antibody reactivities to 39 EBV-peptides in MS patients (n=29) compared to healthy controls (n=22). Seventeen of the 39 peptides were from EBNA-1 and 13 located within the glycine-alanine repeat of EBNA-1. Further reactivities were directed against EBNA-3, EBNA-4, EBNA-6, VP26, and LMP1. Thus, antibodies against EBV in MS patients primarily target, but are not confined to, the glycine-alanine repeat of EBNA-1.
Keywords:	Multiple Sclerosis, Epstein-Barr Virus, Epstein-Barr Nuclear Antigen-1, Glycine-Alanine Repea, Antibodies, Peptide Array
Source:	Journal of Neuroimmunology
ISSN:	0165-5728
Publisher:	Elsevier
Volume:	272
Number:	1-2
Page Range:	56-61
Date:	15 July 2014
Official Publication:	https://doi.org/10.1016/j.jneuroim.2014.04.005
PubMed:	View item in PubMed

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