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| Item Type: | Article |
|---|---|
| Title: | Plasmodium chabaudi chabaudi: differential susceptibility of gene-targeted mice deficient in IL-10 to an erythrocytic-stage infection |
| Creators Name: | Linke, A, Kühn, R., Müller, W, Honarvar, N, Li, C and Langhorne, J |
| Abstract: | Female and male mice deficient in IL-10 production by targeted disruption of the IL-10 gene were infected with Plasmodium chabaudi chabaudi (AS) blood-stage parasites. Both male and female mutant mice exhibited more severe signs of disease than did +/+ or heterozygous control mice. Female defective mice also displayed an increased mortality; 56% of mice died within 20 days of infection. Mortality did not appear to be due to a fulminating parasitemia as death occurred at different levels of parasitemia in the individual mice. The acute infection was accompanied by an enhanced Th1 IFN-gamma response. This response was retained in the chronic phase of infection of both male and female mutant mice, whereas in controls the responding CD4+ T cells were predominantly Th2 cells secreting IL-4. The data suggest that IL-10 regulates the inflammatory response to the parasite and that in its absence the combined effects of malaria toxins and the sustained or enhanced IFN-gamma response lead to increased pathology. In the case of female mice absence of IL-10 is sufficient to induce a lethal endotoxin-like reaction. |
| Keywords: | Plasmodium chabaudi, Malaria, IL-10-Deficient Mice, Malarial Pathology, Animals, Mice |
| Source: | Experimental Parasitology |
| ISSN: | 0014-4894 |
| Publisher: | Academic Press |
| Volume: | 84 |
| Number: | 2 |
| Page Range: | 253-263 |
| Date: | November 1996 |
| Official Publication: | https://doi.org/10.1006/expr.1996.0111 |
| PubMed: | View item in PubMed |
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